"Scar Tissue" is the first single from the American alternative rock band Red Hot Chili Peppers' seventh studio album Californication, released in 1999. It is one of their most successful songs, spending a then-record 16 consecutive weeks on top of the Billboard Hot Modern Rock Tracks chart, as well as 10 weeks at the top of the Billboard Mainstream Rock Tracks chart and reached #8 on Billboard Hot 100 Airplay. It peaked at #9 on the Billboard Hot 100. In the UK, the song reached #15 on the UK Singles Chart. It won a Grammy Award for Best Rock Song in 2000. The song is notable for its mellow intro guitar riff and for its slide guitar solos throughout. Guitar World placed the guitar solo 63rd in its list of the "100 Greatest Guitar Solos".
"Scar Tissue" has been a live staple in the band's setlists since its first performance in 1998 making it the band's third most performed song ever behind only "Give It Away" and "Under the Bridge"